Resident Evil: Revelations
Resident Evil: Revelations is coming to Xbox 360 and PlayStation 3, but the Wii U version is the only one that will let players play with two screens like the original release.
Along with some features you would expect, like having the map relegated to the GamePad, you will also be able to play off-screen (something confirmed last month), and interact with the MiiVerse in humorous and helpful ways.
For more on Resident Evil: Revelations, you can check out the developer diaries that Capcom has released for the game. This one covers the heritage of the Resident Evil franchise, and this one explains why viruses are terrifying.