It is important to consider Doxycycline as a possible cause of seizures — even when used at recommended doses. Muscarinic receptors are known to be involved in neuronal function in the brain and autonomic nervous system, and much attention has been paid to these receptors as targets of analgesic drugs in the central nervous system. Doxycycline can impair thinking and the physical abilities required for driving or operating machinery. This may not be a complete list of all interactions that may occur. Although Doxycycline is not classified as a narcotic, it may become habit-forming, causing mental or physical dependence. Although its mode of action is not completely understood, from animal tests, at least two complementary mechanisms appear applicable: binding of parent and M1 metabolite to ?-opioid receptors and weak inhibition of reuptake of norepinephrine and serotonin .order Doxycycline When large doses of Doxycycline are administered with anesthetic medications or alcohol, respiratory depression may result. Clinicians should also maintain a high index of suspicion for adverse drug reaction when evaluating altered mental status in these patients

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