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"Physical reality” isn’t some arbitrary demarcation. It is defined in terms of what we can systematically investigate, directly or not, by means of our senses. It is preposterous to assert that the process of systematic scientific reasoning arbitrarily excludes “non-physical explanations” because the very notion of “non-physical explanation” is contradictory.
In an infinite universe where reality is interpreted through our continuously fluctuating perception, providing absolute definitive proof of anything becomes a little more than speculation based on random data.