The lights are on
Are you a whovian? Is your preferred method of travel police box? Do you enjoy your cheese and your drama together? Then this is probably for you.
I think it'd be an interesting twist, and I think I'd enjoy it. (Especially if she was a ginger, and possibly Irish) Maybe have a guy as the main companion as well to balance it out?
I'm sorry but I have to just squash this once and for all with no mercy. I am sick of seeing this! The doctor is a time lord. Just because he is an alien does not mean he is asexual! He is a male! Regenerating alters his appearance. It does not rewrite his sex! It would make no sense if this happened.
I agree Shish!!! He is a HE!!
I forget which episode exactly, but in one of the older Who episodes, The Doctor talks about how it's totally possible for a Time Lord to change sex during regeneration. As a matter of fact, there is an audio series called "Doctor Who: Unbound" that takes place in The Doctor's future and, while it's not considered cannon to the show, he regenerates into a woman in one of the stories. Finally, in the Season 6 episode "The Doctor's Wife" The Corsair, who is a Time Lord, regenerates into a woman. So, it not only can happen, it HAS happened a couple of times in official Doctor Who stories, once in official cannon.
Someone else pointed out that when The Doctor regenerates from David Tennant to Matt Smith, he initially thinks that he is a girl because of his hair, indicating that it's totally possible for him to regen into a woman.
I don't know how I would feel if the next Doctor was a woman...if they picked the right woman for it though I guess it could be very interesting.