The lights are on
My vote absolutely goes to Sega Genesis classic "Kid Chameleon". You get different helmets that give you various power-ups, and the game is extremely long!
If you can't find a Genesis copy, its available right now on Wii virtual console, as well as in lots of various Sega collection packs on PS2, PS3, etc.
"For today we shall give birth to a child, an his name shall be BACON." -Wallace Wells
Eternal Champions and Earthworm Jim from Genesis. Not really retro but a remake of Manhunt from PC / PS2, or better yet a TRUE sequel. SUCH A GREAT GAME.
I, along with many Final Fantasy faithful, have wished for years that Final Fantasy VII would be remade to current generation specs. There is so much great about that game. HD graphics and a revamped sound track would make the game even greater.
rock n roll racing !
joust was one of my favorite retro games to play with friends
This is a handheld system retro. Since the 3DS incorporates a lot of apps and downloadable gems, I would love to see any of the gameboy or gameboy advanced pokemon games to buy in the Nintendo eshop.
Earthbound (North America release) - technically not a remake so much as a release, but this could potentially be remade.
A Harvest Moon 64 remake would be great!
and Super Mario RPG as well.
Resident Evil 2, Dino Crisis (both 1 and 2)
Chrono Trigger from the SNES. I know there was a sequel (Chrono Cross) but that's not the same!
We need a new 2d metroid game or remake at least. Metroid in 3d I haven't even played but completely ruins the name metroid.
Strike Commander, a not-so well-known combat flight sim heavily influenced by the Wing Commander series.
Combat flight sims (and flight sims in general) aren't as popular nowadays as they used to be, possibly due to the complexity of the genre, or maybe because flight sims are percieved aas being too 'mundane' in comparison to other types of games.
I mentioned Strike Commander because it challenges both of those potential issues: it's a combat flight sim sure, but the flight model it utilizes is considerably more simple than that of other combat flight sims released around the same time. The game is also story-driven, something which can't be said about a lot of other flight sims, both past and present. Those two factors might give a modern remake of Strike Commander a place in today's market.
Where Good Ideas Come From, by Steven Johnson
Blood Will Tell from the PS2. Not that long ago, but more than deserving.
These are my top choices:
Far Cry 3
The Legend of Zelda: Twilight Princess
Dark Souls 1 and 2
Resident Evil series
Dead Space 2
Red Dead Redemption
Elder Scrolls V: Skyrim
The Dark Cloud series absolutely deserves a reboot, remake, or remaster.