The lights are on
There aren't any that I know of, since the form does lend itself to gaming much...
But use your imagination. Pick a sunday comic, and let loose on how it would be made into a game.
I would like to see a Calvin and Hobbes game done via the old Sierra/Lucasarts adventure gaming style. Puzzles, bizzare situations, comic mischief, and oddly thought-proving dialogue between a 6 year-old and a stuffed tiger sounds ripe for adaptation.
Not that Bill Watterson would ever consent to such a thing.
Alright guys. Your turn.